Synonyms: 6030405P19Rik,AI429776,B830038C02Rik,Brain and reproductive organ expressed (TNFRSF1A modulator),brain and reproductive organ expressed protein,Brain and reproductive organ-expressed protein,BRCA1 A complex subunit BRE,BRCA1-A complex subunit BRE,BRCA1/BRCA2 containing complex subunit 4,BRCA1/BRCA2 containing complex subunit 45,BRCA1/BRCA2-containing complex subunit 45,BRCC4,BRCC45,bre,BRE
Background: This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer.