Synonyms: [methionine synthase] cobalamin methyltransferase (cob(II)alamin reducing) ,5 methyltetrahydrofolate homocysteine methyltransferase reductase,cblE,Methionine synthase reductase,Methionine synthase reductase, mitochondrial,MGC129643,MSR
Background: This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants.