MTRR Antikörper (N-Term)

Produktnummer ABIN2787324

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-MTRR Antikörper wird verwendet zum Nachweis von MTRR in Proben von Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd und Schwein. Er wurde validiert für WB und IHC.

Kurzübersicht für MTRR Antikörper (N-Term) (ABIN2787324)

Target: MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTRR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MTRR Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: MTRR Antibody - N-terminal region

Sequenz: YDLKTETAPL VVVVSTTGTG DPPDTARKFV KEIQNQTLPV DFFAHLRYGL

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MTRR. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MTRR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57657-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MTRR Antikörper (ABIN2787324)

Richard, Desviat, Ugarte, Pérez: "Oxidative stress and apoptosis in homocystinuria patients with genetic remethylation defects." in: Journal of cellular biochemistry, Vol. 114, Issue 1, pp. 183-91, (2012) (PubMed).

Details zu MTRR

Target: MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR))

Andere Bezeichnung: MTRR

Hintergrund:

Background Information: Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Gene Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Alternative Symbols: MSR, cblE

Protein Name: Methionine synthase reductase

Molekulargewicht: 80kDa

Gen-ID: 4552

NCBI Accession: NP_076915

UniProt: Q9UBK8

Pathways: Methionine Biosynthetic Process