Synonyms: HLA class I antigen,FLJ36918,FLJ60820,MGC111087,MGC21250,MHC class I chain related gene A protein,MHC class I chain related protein A,MHC class I chain related protein A HLA B HLA C,MHC class I polypeptide related sequence A,MHC class I polypeptide-related sequence A,MHC class I related protein,MIC A,MIC-A,micA,MICA,OTTHUMP00000029088,OTTHUMP00000044528,OTTHUMP00000165170,OTTHUMP00000165172,PERB11.1,Stress inducible class I homolog
Background: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.