UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) Antikörper

Details zu Produkt Nr. ABIN6567949
Target
Reaktivität
Human, Ratte
32
5
5
2
1
1
1
1
1
Wirt
Kaninchen
25
7
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
3
3
3
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
24
22
16
5
1
Optionen
Immunogen Recombinant protein of human UPF2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung UPF2 (UPF2 Antibody Abstract)
Hintergrund

Synonyms: DKFZp434D222,hUpf2,KIAA1408,MGC138834,MGC138835,Nonsense mRNA reducing factor 2,Regulator of nonsense transcripts 2,RENT2,RENT2,Smg 3,Smg 3 homolog nonsense mediated mRNA decay factor,Up-frameshift suppressor 2 homolog,UPF2,UPF2 regulator of nonsense transcripts homolog,UROC1,Urocanate hydratase,Yeast Upf2p homolog

Background: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene, both variants encode the same protein.

Molekulargewicht

Observed_MW: 180kDa

Calculated_MW: 66kDa/147kDa

Gen-ID 26019
UniProt Q9HAU5
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) antibody (ABIN6567949) Western blot analysis of extracts of various cell lines, using UPF2 antibody.
Image no. 2 for anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) antibody (ABIN6567949) Immunohistochemistry of paraffin-embedded rat kidney using UPF2 antibody.