NUDT1 Antikörper (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1)

Details for Product anti-NUDT1 Antibody No. ABIN6567883
Target
Reaktivität
Human
30
11
11
Wirt
Kaninchen
25
6
Klonalität
Polyklonal
Konjugat
Dieser NUDT1 Antikörper ist unkonjugiert
2
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
20
12
9
4
3
2
1
1
1
1
Optionen
Immunogen Recombinant protein of human NUDT1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung NUDT1 (NUDT1 Antibody Abstract)
Hintergrund

Synonyms: 2-hydroxy-dATP diphosphatase,7 8 dihydro 8 oxoguanine triphosphatase,7,8 oxo 7 8 dihydrodeoxyguanosine triphosphatase,8 oxo 7 8 dihydroguanosine triphosphatase,8 oxo dGTPase,8-dihydro-8-oxoguanine triphosphatase,8-oxo-dGTPase,8ODP,MTH 1,MTH1,MutT human homolog 1,Nucleoside diphosphate linked moiety X motif 1,Nucleoside diphosphate linked moiety X type motif 1,Nucleoside diphosphate-linked moiety X motif 1,Nudix (nucleoside diphosphate linked moiety X) type motif 1,Nudix hydrolase 1,Nudix motif 1,Nudix type motif 1,NUDT 1,Nudt1

Background: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Molekulargewicht

Observed_MW: Refer to Figures

Calculated_MW: 17kDa/19kDa/20kDa/22kDa

Gen-ID 4521
UniProt P36639
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:20 - 1:50
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) antibody (ABIN6567883) Immunoprecipitation analysis of 200ug extracts of 293T cells using 1ug NUDT1 antibody.
Image no. 2 for anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) antibody (ABIN6567883) Western blot analysis of extracts of various cell lines, using NUDT1 antibody.
Image no. 3 for anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) antibody (ABIN6567883) Immunohistochemistry of paraffin-embedded human gastric cancer using NUDT1 antibody.