NUDT1 Antikörper
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- Target Alle NUDT1 Antikörper anzeigen
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NUDT1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- This antibody ist KO validated.
- Aufreinigung
- Affinity purification
- Güteklasse
- KO Validated
- Immunogen
- Recombinant fusion protein of human NUDT1 (NP_945192.1).
- Isotyp
- IgG
- Top Product
- Discover our top product NUDT1 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000 IHC 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
- Andere Bezeichnung
- NUDT1 (NUDT1 Produkte)
- Synonyme
- mutT antikoerper, nudT1 antikoerper, MTH1 antikoerper, Mth1 antikoerper, 7,8-dihydro-8-oxoguanine triphosphatase antikoerper, nudix hydrolase 1 antikoerper, nudix (nucleoside diphosphate linked moiety X)-type motif 1 antikoerper, mth1 antikoerper, Tsp_07498 antikoerper, nudt1 antikoerper, 8odp antikoerper, NUDT1 antikoerper, Nudt1 antikoerper
- Hintergrund
- Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
- Molekulargewicht
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Observed_MW: Refer to Figures
Calculated_MW: 17kDa/19kDa/20kDa/22kDa
- Gen-ID
- 4521
- UniProt
- P36639
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