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NUDT1 Antikörper (AA 1-179)

NUDT1 Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6144926
  • Target Alle NUDT1 Antikörper anzeigen
    NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
    Bindungsspezifität
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-179
    Reaktivität
    • 29
    • 13
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 26
    • 3
    Kaninchen
    Klonalität
    • 25
    • 4
    Polyklonal
    Konjugat
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NUDT1 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 8
    • 6
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Sequenz
    MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE SDEMRPCWFQ LDQIPFKDMW PDDSYWFPLL LQKKKFHGYF KFQGQDTILD YTLREVDTV
    Kreuzreaktivität
    Human
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human MTH1 (NP_945192.1).
    Isotyp
    IgG
    Top Product
    Discover our top product NUDT1 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IP,1:20 - 1:50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
    Andere Bezeichnung
    NUDT1 (NUDT1 Produkte)
    Synonyme
    mutT antikoerper, nudT1 antikoerper, MTH1 antikoerper, Mth1 antikoerper, 7,8-dihydro-8-oxoguanine triphosphatase antikoerper, nudix hydrolase 1 antikoerper, nudix (nucleoside diphosphate linked moiety X)-type motif 1 antikoerper, mth1 antikoerper, Tsp_07498 antikoerper, nudt1 antikoerper, 8odp antikoerper, NUDT1 antikoerper, Nudt1 antikoerper
    Hintergrund
    Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.,NUDT1,MTH1,Epigenetics & Nuclear Signaling,DNA Damage & Repair,NUDT1
    Molekulargewicht
    17 kDa/19 kDa/20 kDa/22 kDa
    Gen-ID
    4521
    UniProt
    P36639
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