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NUDT1 Antikörper (Internal Region)

NUDT1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6263763
  • Target Alle NUDT1 Antikörper anzeigen
    NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
    Bindungsspezifität
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 29
    • 12
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 26
    • 3
    Kaninchen
    Klonalität
    • 25
    • 4
    Polyklonal
    Konjugat
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NUDT1 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 7
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    NUDT1 Antibody detects endogenous levels of total NUDT1.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human NUDT1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product NUDT1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
    Andere Bezeichnung
    NUDT1 (NUDT1 Produkte)
    Synonyme
    mutT antikoerper, nudT1 antikoerper, MTH1 antikoerper, Mth1 antikoerper, 7,8-dihydro-8-oxoguanine triphosphatase antikoerper, nudix hydrolase 1 antikoerper, nudix (nucleoside diphosphate linked moiety X)-type motif 1 antikoerper, mth1 antikoerper, Tsp_07498 antikoerper, nudt1 antikoerper, 8odp antikoerper, NUDT1 antikoerper, Nudt1 antikoerper
    Hintergrund

    Description: Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).

    Gene: NUDT1

    Molekulargewicht
    22kDa
    Gen-ID
    4521
    UniProt
    P36639
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