APOB Antikörper (Apolipoprotein B)

Details for Product anti-APOB Antibody No. ABIN6567867
Target
Reaktivität
Human, Maus, Ratte
144
31
24
8
4
1
1
Wirt
Kaninchen
72
56
34
4
4
Klonalität
Polyklonal
Konjugat
Dieser APOB Antikörper ist unkonjugiert
24
18
10
8
7
6
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
86
82
39
34
19
17
14
13
12
10
10
9
4
4
2
2
1
1
1
1
1
1
Optionen
Immunogen Recombinant protein of human APOB
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung APOB (APOB Antibody Abstract)
Hintergrund

Synonyms: Apo B-100,Apo B-48,ApoB 100,ApoB 48,APOB,APOB,Apolipoprotein B (including Ag(x) antigen),Apolipoprotein B 100,Apolipoprotein B,Apolipoprotein B-48,Apolipoprotein B48,FLDB,LDLCQ4

Background: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

Molekulargewicht

Observed_MW: 110kDa

Calculated_MW: 515kDa

Gen-ID 338
UniProt P04114
Pathways Lipid Metabolism
Applikations-hinweise WB 1:200 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Apolipoprotein B (APOB) antibody (ABIN6567867) Western blot analysis of extracts of various cell lines, using APOB antibody.