Synonyms: 2-dihydrobenzene-1,2-diol dehydrogenase,20 alpha (3 alpha) hydroxysteroid dehydrogenase,20 ALPHA HSD,20 alpha hydroxysteroid dehydrogenase,20-alpha-HSD,20-alpha-hydroxysteroid dehydrogenase,20ALPHAHSD,2ALPHAHSD,AK1C1,AK1C1,AKR1C1,Aldo keto reductase family 1 member C1,aldo-keto reductase C,Aldo-keto reductase family 1 member C1,Aldo-keto reductase family,1 member 1,C9,Chlordecone reductase homolog,Chlordecone reductase homolog HAKRC,DD1,DD1/DD2,DDH,DDH1,Dihydrodiol dehydrogenase 1,Dihydrodiol dehydrogenase 1/2,dihydrodiol dehydrogenase 1,20-alpha (3-alpha)-hydroxysteroid dehydrogenase,dihydrodiol dehydrogenase isoform DD1,Dihydrodiol dehydrogenase,type 1,H37,HAKRC,HBAB,Hepatic dihydrodiol dehydrogenase,High affinity hepatic bile acid-binding protein,High-affinity hepatic bile acid-binding protein,Indanol dehydrogenase,MBAB,MGC8954,Trans-1,Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase,Type II 3 alpha hydroxysteroid dehydrogenase
Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.