ADAM17 Antikörper

Produktnummer ABIN6566679

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ADAM17 in IHC. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für ADAM17 Antikörper (ABIN6566679)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM17 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-ADAM17 Antikörper

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human ADAM17 (NP_003174.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Andere Bezeichnung: ADAM17

Hintergrund: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.

Molekulargewicht:

Observed_MW: 115kDa

Calculated_MW: 78kDa/93kDa

Gen-ID: 6868

UniProt: P78536

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus