GCK Antikörper (Glucokinase (Hexokinase 4))

Details for Product anti-GCK Antibody No. ABIN6566589
Target
Reaktivität
Human, Maus, Ratte
90
37
23
3
2
2
2
1
1
1
1
Wirt
Kaninchen
83
11
Klonalität
Polyklonal
Konjugat
Dieser GCK Antikörper ist unkonjugiert
9
6
5
5
4
4
2
1
1
1
1
1
1
Applikation
Immunofluorescence (IF)
79
51
49
15
13
9
8
5
4
2
2
1
1
1
Optionen
Immunogen Recombinant protein of human GCK
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung GCK (GCK Antibody Abstract)
Hintergrund

Synonyms: ATP:D-hexose 6-phosphotransferase,FGQTL3,GCK,GK,GLK,Glucokinase,Hexokinase D pancreatic isozyme,Hexokinase type IV,Hexokinase-4,Hexokinase-D,HHF3,HK IV,HK4,HKIV,HXK4,HXKP,LGLK,MODY2

Background: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Molekulargewicht

Calculated_MW: 52kDa

Gen-ID 2645
UniProt P35557
Pathways MAPK Signalweg, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process
Applikations-hinweise IF 1:20 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Glucokinase (Hexokinase 4) (GCK) antibody (ABIN6566589) Immunofluorescence analysis of HeLa cells using GCK antibody.