BRCA1 Antikörper (Breast Cancer 1)

Details for Product anti-BRCA1 Antibody No. ABIN6566504
Target
Reaktivität
Human, Maus
262
31
21
4
2
1
1
1
Wirt
Kaninchen
200
65
4
2
Klonalität
Polyklonal
Konjugat
Dieser BRCA1 Antikörper ist unkonjugiert
21
10
9
8
8
8
8
8
7
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
136
89
66
62
48
42
41
27
19
18
16
9
6
3
3
2
2
1
Optionen
Immunogen A synthetic peptide of human BRCA1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung BRCA1 (BRCA1 Antibody Abstract)
Hintergrund

Synonyms: BRCA 1,BRCA1,BRCA1 DNA repair associated,BRCA1/BRCA2 containing complex subunit 1,BRCA1/BRCA2-containing complex,subunit 1,BRCA1,BRCAI,BRCC 1,BRCC1,Breast and ovarian cancer susceptibility protein 1,Breast Cancer 1,Breast Cancer 1 Early Onset,Breast cancer type 1 susceptibility protein,BROVCA1,FANCS,IRIS,PNCA4,PPP1R53,Protein phosphatase 1 regulatory subunit 53,PSCP,RING finger protein 53,RNF53

Background: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Molekulargewicht

Observed_MW: 85kDa

Calculated_MW: 7kDa/78-85kDa/202-210kDa

Gen-ID 672
UniProt P38398
Pathways Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Breast Cancer 1 (BRCA1) antibody (ABIN6566504) Western blot analysis of extracts of various cell lines, using BRCA1 antibody.
Image no. 2 for anti-Breast Cancer 1 (BRCA1) antibody (ABIN6566504) Immunohistochemistry of paraffin-embedded human prostate using BRCA1 antibody.
Image no. 3 for anti-Breast Cancer 1 (BRCA1) antibody (ABIN6566504) Immunohistochemistry of paraffin-embedded human breast cancer using BRCA1 antibody.
Image no. 4 for anti-Breast Cancer 1 (BRCA1) antibody (ABIN6566504) Immunofluorescence analysis of A549 cells using BRCA1 antibody.