PINK1 Antikörper (C-Term)

Produktnummer ABIN652208

Der Kaninchen Polyklonal Anti-PINK1-Antikörper wurde für WB validiert. Er ist geeignet, PINK1 in Proben von Human und Maus zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für PINK1 Antikörper (C-Term) (ABIN652208)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB6517

Produktdetails anti-PINK1 Antikörper

Bindungsspezifität: AA 493-526, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Park6(PINK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-526 amino acids from the C-terminal region of human Park6(PINK1).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PINK1 Antikörper (ABIN652208)

Berthier, Jiménez-Sáinz, Pulido: "PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 36, pp. 14729-34, (2013) (PubMed).

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: Park6 (PINK1)

Hintergrund: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Molekulargewicht: 62769

Gen-ID: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagie