KAP1 Antikörper

Produktnummer ABIN645876

Der Ziege not_set anti-KAP1 Antikörper (ABIN645876) detektiert spezifisch KAP1. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für KAP1 Antikörper (ABIN645876)

Target: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Reaktivität: Human, Maus

Wirt: Ziege

Konjugat: Dieser KAP1 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktdetails anti-KAP1 Antikörper

Spezifität: The Goat anti-KAP1 / TRIM28 antibody detects protein derived from human recombinant protein and HepG2 lysate at various concentrations.

Kreuzreaktivität: Human, Maus

Produktmerkmale: Goat Anti-KAP1 / TRIM28

Immunogen: Peptide with sequence C-SSQELSGGPGDGP, from the C Terminus of the protein sequence according to NP_005753, was used as an immunogen.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Supplied as 100µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Lagerung: -20 °C

Details zu KAP1

Target: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Andere Bezeichnung: KAP1 / TRIM28

Hintergrund: KAP1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger. KAP1 has been shown to form complexes with KRAB domain transcription factors and increase the efficiency with which they mediate repression. KAP1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel associated box containing zinc finger protein 1). KAP1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, helping to regulate transcriptional repression. Recent studies have shown that KAP1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.

NCBI Accession: NP_005753

Pathways: Hedgehog Signalweg, Positive Regulation of Response to DNA Damage Stimulus