HLA-ABC Antikörper
Kurzübersicht für HLA-ABC Antikörper (ABIN642915)
Target
Alle HLA-ABC Antikörper anzeigenReaktivität
Wirt
Konjugat
Applikation
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Spezifität
- The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. These proteins are found on the surface of almost all nucleated somatic cells. DS-MB-01537 recognizes a monomorphic determinant on the human HLA Class I heavy chain. Epitope analysis has shown that this antibody binds in the alpha1 domain. Recent studies have shown that this antibody may be able to induce apoptosis in activated but not resting T cells (1).
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Produktmerkmale
- Rat Anti-Human HLA ABC
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Aufreinigung
- Purified
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Immunogen
- PhA activated human peripheral blood lymphocytes.
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Isotyp
- IgG2b
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- IgG concentration 1.0 mg/ml
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Buffer
- Phosphate buffered saline
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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- HLA-ABC
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Andere Bezeichnung
- HLA ABC
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Hintergrund
- This antibody does not cross reacts with Fab or F(ab')2 of IgG. Some cross reaction with IgG of other species such as horse and sheep was observed. No cross reaction with human IgA, IgE or IgM.
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Pathways
- T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
Target
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