Presenilin 2 Antikörper
Kurzübersicht für Presenilin 2 Antikörper (ABIN636358)
Target
Alle Presenilin 2 (PSEN2) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Aufreinigung
- Purified
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Applikationshinweise
- Optimal conditions should be determined byt he investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- Lot specific
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.
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- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
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Andere Bezeichnung
- Presenilin 2
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Hintergrund
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP.
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Pathways
- Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung
Target
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