FEN1 Antikörper

Produktnummer ABIN6298330

Produktdetails anti-FEN1 Antikörper

Target: FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FEN1 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Verwendungszweck: Rabbit Anti-FEN1 Antibody,

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu FEN1

Target: FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

Andere Bezeichnung: FEN1 (FEN1 Produkte)

Synonyme: FEN-1 antikoerper, FEN1 antikoerper, AW538437 antikoerper, MF1 antikoerper, RAD2 antikoerper, cb879 antikoerper, fen-1 antikoerper, fen1 antikoerper, mf1 antikoerper, rad2 antikoerper, xFEN1a antikoerper, flap structure-specific endonuclease 1 antikoerper, flap endonuclease 1-like antikoerper, Flap endonuclease-1 antikoerper, 5'-3' exonuclease family protein antikoerper, flap structure specific endonuclease 1 antikoerper, flap structure-specific endonuclease 1 L homeolog antikoerper, nuclease, Rad2 family antikoerper, FEN1 antikoerper, LOC100808044 antikoerper, Bm1_49605 antikoerper, AT5G26680 antikoerper, Fen1 antikoerper, fen1 antikoerper, fen1.L antikoerper

Hintergrund:

Target Description: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Gene Symbol: FEN1

Gen-ID: 2237

UniProt: P39748

Pathways: Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA