SHC1 Antikörper
Kurzübersicht für SHC1 Antikörper (ABIN6298167)
Target
Alle SHC1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- Rabbit Anti-Shc (Ab-349) Antibody,
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anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 171-280) antibody
SHC1 Reaktivität: Human WB, ELISA, IF, IHC (p), PLA Wirt: Maus Monoclonal 3F4 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibodySHC1 Reaktivität: Human, Maus WB, ELISA, ICC, FACS Wirt: Maus Monoclonal 2F7C7 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 424-440), (C-Term) antibodySHC1 Reaktivität: Human, Maus, Ratte WB, IHC, ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 272-559) antibodySHC1 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr349) antibodySHC1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr427) antibodySHC1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) antibodySHC1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 171-280) antibodySHC1 Reaktivität: Human WB, IHC, ELISA, IF, IHC (p), PLA Wirt: Maus Monoclonal 3F4 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 359-473) antibodySHC1 Reaktivität: Human, Maus, Ratte, Hund, Huhn WB, IF Wirt: Maus Monoclonal 30-SHC unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pSer36) antibodySHC1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- 2-8°C (short-term), -20°C (long-term)
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- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
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Andere Bezeichnung
- Shc
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Hintergrund
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Target Description: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Gene Symbol: SHC1
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Gen-ID
- 6464
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UniProt
- P29353
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Pathways
- RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
Target
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