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CD74 Antikörper

Der Maus Monoklonal Anti-CD74-Antikörper wurde für IHC validiert. Er ist geeignet, CD74 in Proben von Human und Maus zu detektieren.
Produktnummer ABIN6297716

Kurzübersicht für CD74 Antikörper (ABIN6297716)

Target

Alle CD74 Antikörper anzeigen
CD74 (HLA-DR-gamma (CD74))

Reaktivität

  • 209
  • 82
  • 21
  • 16
Human, Maus

Wirt

  • 127
  • 105
  • 4
  • 3
  • 2
Maus

Klonalität

  • 157
  • 80
  • 3
Monoklonal

Konjugat

  • 86
  • 18
  • 15
  • 10
  • 9
  • 7
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Dieser CD74 Antikörper ist unkonjugiert

Applikation

  • 143
  • 134
  • 84
  • 58
  • 44
  • 41
  • 36
  • 27
  • 15
  • 13
  • 13
  • 13
  • 11
  • 10
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (IHC)
  • Verwendungszweck

    Mouse anti-Human/Mouse CD74 Antibody [IHC only]

    Spezifität

    Cell surface and paranuclear globular

    Aufreinigung

    SU-DHL-4 lymphoma cells were used as the immunogen for this CD74 antibody.

    Immunogen

    SU-DHL-4 lymphoma cells were used as the immunogen for this CD74 antibody.
  • Applikationshinweise

    Prediluted format : incubate for 30 min at RT (2)

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • Target

    CD74 (HLA-DR-gamma (CD74))

    Andere Bezeichnung

    HLA class II histocompatibility antigen gamma chain

    Hintergrund

    Target Description: CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. CD74 antibody stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. antibody to CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

    Gene Symbol: CD74///DHLAG

    Gen-ID

    972

    UniProt

    P04233

    Pathways

    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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