CD74 Antikörper

Produktnummer ABIN6297715

Dieser Maus Monoklonal Antikörper erkennt spezifisch CD74 in FACS, WB, IF und IHC. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für CD74 Antikörper (ABIN6297715)

Target: CD74 (HLA-DR-gamma (CD74))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD74 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails anti-CD74 Antikörper

Verwendungszweck: Mouse anti-Human/Mouse CD74 Antibody [Sodium Azide Free]

Spezifität: Cell surface and paranuclear globular

Aufreinigung: SU-DHL-4 lymphoma cells were used as the immunogen for this anti-CD74 antibody.

Immunogen: SU-DHL-4 lymphoma cells were used as the immunogen for this anti-CD74 antibody.

Anwendungsinformationen

Applikationshinweise: Western blot: 1-2 μg/mL
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu CD74

Target: CD74 (HLA-DR-gamma (CD74))

Andere Bezeichnung: HLA class II histocompatibility antigen gamma chain

Hintergrund:

Target Description: CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

Gene Symbol: CD74///DHLAG

Gen-ID: 296

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints