CD74 Antikörper

Produktnummer ABIN6297714

Dieses Anti-CD74-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD74 in FACS, IF und IHC. Geeignet für Human.

Kurzübersicht für CD74 Antikörper (ABIN6297714)

Target: CD74 (HLA-DR-gamma (CD74))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD74 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails anti-CD74 Antikörper

Verwendungszweck: Mouse anti-Human CD74 Antibody Cocktail [Sodium Azide Free]

Spezifität: Cell surface and paranuclear globular

Aufreinigung: SU-DHL-4 lymphoma cells (LN-2) and recombinant full-length human protein (CLIP/813) were used as the immunogen for the CD74 antibody cocktail.

Immunogen: SU-DHL-4 lymphoma cells (LN-2) and recombinant full-length human protein (CLIP/813) were used as the immunogen for the CD74 antibody cocktail.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu CD74

Target: CD74 (HLA-DR-gamma (CD74))

Andere Bezeichnung: HLA class II histocompatibility antigen gamma chain

Hintergrund:

Target Description: It recognizes a protein of ~35 kDa, identified as CD74/CLIP. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

Gene Symbol: CD74///DHLAG

Gen-ID: 296

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints