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CD74 Antikörper

CD74 Reaktivität: Human IHC Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN6297713
  • Target Alle CD74 Antikörper anzeigen
    CD74 (HLA-DR-gamma (CD74))
    Reaktivität
    • 185
    • 65
    • 13
    • 11
    Human
    Wirt
    • 123
    • 80
    • 4
    • 2
    Maus
    Klonalität
    • 140
    • 67
    • 2
    Monoklonal
    Konjugat
    • 71
    • 17
    • 16
    • 10
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser CD74 Antikörper ist unkonjugiert
    Applikation
    • 127
    • 112
    • 80
    • 45
    • 38
    • 36
    • 31
    • 27
    • 18
    • 14
    • 13
    • 11
    • 10
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Verwendungszweck
    Mouse anti-Human CD74 Antibody Cocktail [IHC only]
    Spezifität
    Cell surface and paranuclear globular
    Aufreinigung
    SU-DHL-4 lymphoma cells (LN-2) and recombinant full-length human protein (CLIP/813) were used as the immunogen for the CD74 antibody cocktail.
    Immunogen
    SU-DHL-4 lymphoma cells (LN-2) and recombinant full-length human protein (CLIP/813) were used as the immunogen for the CD74 antibody cocktail.
    Top Product
    Discover our top product CD74 Primärantikörper
  • Applikationshinweise
    Prediluted format : incubate for 30 min at RT (2)
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • Target
    CD74 (HLA-DR-gamma (CD74))
    Andere Bezeichnung
    HLA class II histocompatibility antigen gamma chain (CD74 Produkte)
    Synonyme
    DHLAG antikoerper, HLADG antikoerper, II antikoerper, Ia-GAMMA antikoerper, CLIP antikoerper, Ii antikoerper, INVG34 antikoerper, Iclp-1 antikoerper, iclp1 antikoerper, wu:fb11f09 antikoerper, wu:fb12a01 antikoerper, wu:fb13d06 antikoerper, wu:fk94e07 antikoerper, Iclp-2 antikoerper, cd74 antikoerper, iclp2 antikoerper, zgc:123161 antikoerper, CD74 molecule antikoerper, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain a antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain b antikoerper, CD74 antikoerper, Cd74 antikoerper, cd74a antikoerper, cd74b antikoerper
    Hintergrund

    Target Description: It recognizes a protein of ~35 kDa, identified as CD74/CLIP. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

    Gene Symbol: CD74///DHLAG

    Gen-ID
    296
    UniProt
    P04233
    Pathways
    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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