CD46 Antikörper

Produktnummer ABIN6297689

Der Maus Monoklonal Anti-CD46-Antikörper wurde für FACS und IF validiert. Er ist geeignet, CD46 in Proben von Human und Pavian zu detektieren.

Kurzübersicht für CD46 Antikörper (ABIN6297689)

Target: CD46

Reaktivität: Human, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-CD46 Antikörper

Verwendungszweck: Mouse anti-Human/Baboon CD46 Antibody [Sodium Azide Free]

Spezifität: Cell surface

Aufreinigung: Stimulated human leukocytes were used as the immunogen for the CD46 antibody.

Immunogen: Stimulated human leukocytes were used as the immunogen for the CD46 antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu CD46

Target: CD46

Andere Bezeichnung: Membrane cofactor protein

Hintergrund:

Target Description: Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Gene Symbol: CD46///MCP///MIC10

Gen-ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization