NKX2-1 Antikörper

Produktnummer ABIN6297613

Dieses Maus Monoklonal-Antikörper erkennt spezifisch NKX2-1 in IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für NKX2-1 Antikörper (ABIN6297613)

Target: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NKX2-1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-NKX2-1 Antikörper

Verwendungszweck: Mouse anti-Human/Mouse/Rat TTF1 Antibody [IHC only]

Spezifität: Nuclear

Aufreinigung: Recombinant protein was used as the immunogen for the TTF1 antibody.

Immunogen: Recombinant protein was used as the immunogen for the TTF1 antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu NKX2-1

Target: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Andere Bezeichnung: Homeobox protein Nkx-2.1

Hintergrund:

Target Description: Recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1. TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Gene Symbol: NKX2-1///NKX2A///TITF1///TTF1

Gen-ID: 7080

UniProt: P43699

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour