EGFR Antikörper

Produktnummer ABIN6296699

Der Maus Monoklonal anti-EGFR Antikörper wird verwendet zum Nachweis von EGFR in Proben von Human. Er wurde validiert für FACS, IP, AP, Func, Inhibition, in vivo, Act und ProA.

Kurzübersicht für EGFR Antikörper (ABIN6296699)

Target: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EGFR Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Affinity Purification (AP), Functional Studies (Func), Blocking Antibody (Inhibition), In vivo Studies (in vivo), Activation (Act), Proliferation Assay (ProA)

Produktdetails anti-EGFR Antikörper

Verwendungszweck: Mouse anti-Human EGF Receptor Antibody [Sodium Azide Free]

Spezifität: Cell surface

Aufreinigung: Microsomes from A431 cells were used as the immunogen for this antibody.

Immunogen: Microsomes from A431 cells were used as the immunogen for this antibody.

Anwendungsinformationen

Applikationshinweise: Functional Activity (Inhibition): antibody blocks EGF receptor activation, inhibits A431 cell proliferation, arrests tumor growth in vivo, affinity purification
IP: 1-2 μg/500 μg protein lysate
FACS: 0.5-1 μg/million cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu EGFR

Target: EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung: Epidermal growth factor receptor

Hintergrund:

Target Description: This antibody reacts with the extracellular domain of EGF receptor and blocks the EGF/TGFa  induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGF receptor.  < a href=../search_result.php?search_txt=egfr>EGFR  is type I receptor tyrosine kinase with sequence homology to  < a href=../search_result.php?search_txt=erbb2>ErbB2, -3 -4 or  < a href=../search_result.php?search_txt=her2>HER2, -3 -4. It binds to Epidermal Growth Factor (EGF),  < a href=../search_result.php?search_txt=TGFa>Transforming Growth Factor-a (TGFa), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.

Gene Symbol: EGFR///ERBB///ERBB1///HER1

Gen-ID: 1956

UniProt: P00533

Pathways: NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine