Thymidine Phosphorylase Antikörper

Produktnummer ABIN6296537

Der Maus Monoklonal Anti-Thymidine Phosphorylase-Antikörper wurde für WB, IHC und IP validiert. Er ist geeignet, Thymidine Phosphorylase in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für Thymidine Phosphorylase Antikörper (ABIN6296537)

Target: Thymidine Phosphorylase (TYMP)

Reaktivität: Human, Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Thymidine Phosphorylase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-Thymidine Phosphorylase Antikörper

Verwendungszweck: Mouse anti-Human/Mouse/Rat Thymidine Phosphorylase Antibody / PD-ECGF [Sodium Azide Free]

Spezifität: Cytoplasmic, nuclear

Aufreinigung: Human recombinant full length protein was used as the immunogen for this Thymidine Phosphorylase antibody.

Immunogen: Human recombinant full length protein was used as the immunogen for this Thymidine Phosphorylase antibody.

Anwendungsinformationen

Applikationshinweise: IP: 1-2 μg/500 μg lysate
IHC (FFPE): 1-2 μg/mL for 30 min at RT
WB: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Thymidine Phosphorylase

Target: Thymidine Phosphorylase (TYMP)

Andere Bezeichnung: Thymidine phosphorylase

Hintergrund:

Target Description: Recognizes a 485 amino acid protein (55 kDa monomer / 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), also called Thymidine Phosphorylase (TP, Tymp) or Gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.

Gene Symbol: TYMP///ECGF1

Gen-ID: 1890

UniProt: P19971

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2