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Major Capsid Protein L1 Antikörper

Der Maus Monoklonal Anti--Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, in Proben von Human Papillomavirus 16 (HPV-16) zu detektieren.
Produktnummer ABIN6296477

Kurzübersicht für Major Capsid Protein L1 Antikörper (ABIN6296477)

Target

Major Capsid Protein L1

Reaktivität

  • 4
  • 2
Human Papillomavirus 16 (HPV-16)

Wirt

  • 4
  • 2
Maus

Klonalität

  • 4
  • 2
Monoklonal

Konjugat

  • 3
  • 1
  • 1
  • 1
Unkonjugiert

Applikation

  • 5
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Verwendungszweck

    Mouse anti-Type 16 of Human Papilloma Virus (HPV-16) L1 Antibody [Sodium Azide Free]

    Spezifität

    Nuclear

    Aufreinigung

    Human papilloma virus type 16, major capsid protein L1, was used as the immunogen for the L1 antibody.

    Immunogen

    Human papilloma virus type 16, major capsid protein L1, was used as the immunogen for the L1 antibody.
  • Applikationshinweise

    Western blot: 1-2 μg/mL,ELISA: assay dependent
    Immunofluorescence: 0.5-1 μg/mL
    Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    In 1X PBS, BSA free, sodium azide free

    Konservierungsmittel

    Azide free

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • Target

    Major Capsid Protein L1

    Substanzklasse

    Viral Protein

    Hintergrund

    Target Description: Reacts with a protein of 57 kDa, identified as the L1 protein of human papilloma virus type 16 (HPV-16). Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on the basement membrane to provide initial virion attachment to target cells. Basement membrane is exposed only after epithelium trauma. Additionally, the alpha6 integrin complexed with either beta1 or beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, integrin complexed with beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, the virion enters the host cell via clathrin-mediated endocytosis and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. [UniProt]The antibody reacts very strongly with formalin-fixed, paraffin-embedded tissues containing HPV-16 or -33, very weak reactions were occasionally observed with biopsy specimens or smears containing HPV-6 or HPV-11. It cross-reacts with HPV37.

    Gene Symbol: L1

    UniProt

    P03101
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