Major Capsid Protein L1 Antikörper

Produktnummer ABIN1045681

Produktdetails

Target: Major Capsid Protein L1

Reaktivität: Human Papillomavirus (HPV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant HPV18 Major capsid protein L1 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.03 % Proclin 300, 50 % Glycerol, 0.01 M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Shipped at 4 °C. Upon delivery aliquot and store at -20 °C or -80 °C.

Antigendetails

Target: Major Capsid Protein L1

Synonyme: major capsid protein L1 antikoerper, L1 antikoerper

Substanzklasse: Viral Protein

Hintergrund: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on the basement membrane to provide initial virion attachment to target cells. Basement membrane is exposed only after epithelium trauma. Additionally, the alpha6 integrin complexed with either beta1 or beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, integrin complexed with beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, the virion enters the host cell via clathrin-mediated endocytosis and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Synonyms: L1

UniProt: P06794