BRCA1 Antikörper (AA 445-620)

Produktnummer ABIN6294532

Dieses Maus Monoklonal-Antikörper erkennt spezifisch BRCA1 in ELISA, IF, FACS und Coat. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für BRCA1 Antikörper (AA 445-620) (ABIN6294532)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BRCA1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Coating (Coat)

Produktdetails anti-BRCA1 Antikörper

Bindungsspezifität: AA 445-620

Verwendungszweck: Mouse anti-Human BRCA1 Antibody (Breast Marker) [Sodium Azide Free]

Spezifität: Nuclear, cytoplasmic

Aufreinigung: Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.

Immunogen: Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL,ELISA: order the BSA free formulation for coating

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Andere Bezeichnung: Breast cancer type 1 susceptibility protein

Hintergrund:

Target Description: BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Gene Symbol: BRCA1///RNF53

Gen-ID: 672

UniProt: P38398

Pathways: Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus