Topoisomerase II alpha Antikörper (AA 1352-1493)

Produktnummer ABIN6294306

Dieser Anti-Topoisomerase II alpha Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von Topoisomerase II alpha in WB, IHC, IF und FACS. Geeignet für Human.

Kurzübersicht für Topoisomerase II alpha Antikörper (AA 1352-1493) (ABIN6294306)

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Topoisomerase II alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-Topoisomerase II alpha Antikörper

Bindungsspezifität: AA 1352-1493

Verwendungszweck: Mouse anti-Human TOP2A Antibody / Topoisomerase II alpha [Sodium Azide Free]

Spezifität: Nuclear

Aufreinigung: Amino acids 1352-1493 from the human protein were used as the immunogen for this TOP2A antibody.

Immunogen: Amino acids 1352-1493 from the human protein were used as the immunogen for this TOP2A antibody.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/10^6 cells in 0.1ml
IF: 1-2 μg/mL
Western blot: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Topoisomerase II alpha

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Andere Bezeichnung: DNA topoisomerase 2-alpha

Hintergrund:

Target Description: This mAb recognizes an ~170 kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.

Gene Symbol: TOP2A///TOP2

Gen-ID: 7153

UniProt: P11388

Pathways: Zellzyklus, Mitotic G1-G1/S Phases