TYROBP Antikörper

Produktnummer ABIN6291980

Der Kaninchen Polyklonal Anti-TYROBP-Antikörper wurde für WB validiert. Er ist geeignet, TYROBP in Proben von Maus und Ratte zu detektieren.

Kurzübersicht für TYROBP Antikörper (ABIN6291980)

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYROBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TYROBP Antikörper

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human TYROBP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Kommentare:

Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes, Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen, Also found in bone marrow, lymph nodes, placenta, lung and liver, Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Details zu TYROBP

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Andere Bezeichnung: TYROBP

Hintergrund: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70  kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Molekulargewicht: 12.179 kDa

Gen-ID: 7305

UniProt: O43914