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TJP1 Antikörper

Dieses Anti-TJP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TJP1 in WB, IHC, ELISA, IF und ICC. Geeignet für Human, Maus, Ratte und Schwein. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.
Produktnummer ABIN6268691

Kurzübersicht für TJP1 Antikörper (ABIN6268691)

Target

Alle TJP1 Antikörper anzeigen
TJP1 (Tight Junction Protein 1 (TJP1))

Reaktivität

  • 66
  • 39
  • 38
  • 20
  • 18
  • 9
  • 6
  • 6
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Schwein

Wirt

  • 61
  • 6
  • 3
  • 1
  • 1
Kaninchen

Klonalität

  • 62
  • 10
Polyklonal

Konjugat

  • 48
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TJP1 Antikörper ist unkonjugiert

Applikation

  • 60
  • 26
  • 23
  • 18
  • 18
  • 16
  • 14
  • 13
  • 13
  • 11
  • 8
  • 3
  • 2
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Spezifität

    ZO 1 Antibody detects endogenous levels of total ZO 1

    Kreuzreaktivität

    Human, Maus, Schwein, Ratte (Rattus)

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human ZO 1

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200, IF 1:100-1:500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C.Stable for 12 months from date of receipt

    Haltbarkeit

    12 months
  • Wang, Lu, Xie, Xiong, Huang, Wei, Jiang, Peng: "Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7." in: International immunopharmacology, Vol. 58, pp. 64-71, (2018) (PubMed).

    Zou, Xiang, Wang, Peng, Wei: "Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model." in: BioMed research international, Vol. 2016, pp. 5436738, (2017) (PubMed).

  • Target

    TJP1 (Tight Junction Protein 1 (TJP1))

    Andere Bezeichnung

    ZO 1

    Hintergrund

    Description: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).

    Gene: TJP1

    Molekulargewicht

    195 kDa

    Gen-ID

    7082

    UniProt

    Q07157

    Pathways

    Carbohydrate Homeostasis, Cell-Cell Junction Organization
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