MAPT Antikörper (C-Term)

Produktnummer ABIN6263123

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAPT in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für MAPT Antikörper (C-Term) (ABIN6263123)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MAPT Antikörper

Bindungsspezifität: C-Term

Spezifität: Tau Antibody detects endogenous levels of total Tau.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Tau, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: MAPT

Hintergrund:

Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Gene: MAPT

Molekulargewicht: 83kDa

Gen-ID: 4137

UniProt: P10636

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size