KPNA1 Antikörper (N-Term)

Produktnummer ABIN6262862

Produktdetails anti-KPNA1 Antikörper

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: KPNA1 Antibody detects endogenous levels of total KPNA1.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KPNA1, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu KPNA1

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Andere Bezeichnung: KPNA1 (KPNA1 Produkte)

Synonyme: IPOA5 antikoerper, NPI-1 antikoerper, RCH2 antikoerper, SRP1 antikoerper, AW494490 antikoerper, NPI1 antikoerper, Rch2 antikoerper, mSRP1 antikoerper, si:ch211-161h7.7 antikoerper, karyopherin subunit alpha 1 antikoerper, importin alpha-1 subunit antikoerper, karyopherin (importin) alpha 1 antikoerper, karyopherin alpha 1 (importin alpha 5) antikoerper, KPNA1 antikoerper, Kpna1 antikoerper, EHI_124900 antikoerper, kpna1 antikoerper

Hintergrund:

Description: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene: KPNA1

Molekulargewicht: 60kDa

Gen-ID: 3836

UniProt: P52294

Pathways: M Phase, Protein targeting to Nucleus