Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Cyclin D2 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-Cyclin D2-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, Cyclin D2 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN6261147

Kurzübersicht für Cyclin D2 Antikörper (C-Term) (ABIN6261147)

Target

Alle Cyclin D2 (CCND2) Antikörper anzeigen
Cyclin D2 (CCND2)

Reaktivität

Human, Maus, Ratte

Wirt

  • 68
  • 23
Kaninchen

Klonalität

  • 71
  • 20
Polyklonal

Konjugat

  • 53
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Cyclin D2 Antikörper ist unkonjugiert

Applikation

  • 68
  • 37
  • 17
  • 15
  • 14
  • 13
  • 13
  • 10
  • 9
  • 8
  • 4
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 16
    • 12
    • 10
    • 7
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    Cyclin D2 Antibody detects endogenous levels of total Cyclin D2.

    Homologie

    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human Cyclin D2, corresponding to a region within C-terminal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    Cyclin D2 (CCND2)

    Andere Bezeichnung

    CCND2

    Hintergrund

    Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

    Gene: CCND2

    Molekulargewicht

    33 kDa

    Gen-ID

    894

    UniProt

    P30279

    Pathways

    Zellzyklus, Mitotic G1-G1/S Phases
Sie sind hier:
Chat with us!