Cyclin C Antikörper (C-Term)

Produktnummer ABIN6261144

Der Kaninchen Polyklonal Anti-Cyclin C-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, Cyclin C in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Cyclin C Antikörper (C-Term) (ABIN6261144)

Target: Cyclin C (CCNC)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-Cyclin C Antikörper

Bindungsspezifität: C-Term

Spezifität: Cyclin C Antibody detects endogenous levels of total Cyclin C.

Homologie: Bovine,Horse,Sheep,Rabbit,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Cyclin C, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Cyclin C

Target: Cyclin C (CCNC)

Andere Bezeichnung: CCNC

Hintergrund:

Description: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Gene: CCNC

Molekulargewicht: 33 kDa

Gen-ID: 892

UniProt: P24863

Pathways: Zellzyklus, Regulation of Lipid Metabolism by PPARalpha