Cyclin C Antikörper (C-Term)
Kurzübersicht für Cyclin C Antikörper (C-Term) (ABIN6261144)
Target
Alle Cyclin C (CCNC) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
- 
    - 
                                            Bindungsspezifität
- C-Term
- 
                                            Spezifität
- Cyclin C Antibody detects endogenous levels of total Cyclin C.
- 
                                            Homologie
- Bovine,Horse,Sheep,Rabbit,Chicken
- 
                                            Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 
                                            Immunogen
- A synthesized peptide derived from human Cyclin C, corresponding to a region within C-terminal amino acids.
- 
                                            Isotyp
- IgG
 
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- 
    - 
                                            Applikationshinweise
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 
                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
- 
                                            
- 
    - 
                                            Format
- Liquid
- 
                                            Konzentration
- 1 mg/mL
- 
                                            Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 
                                            Konservierungsmittel
- Sodium azide
- 
                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 
                                            Lagerung
- -20 °C
- 
                                            Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- 
                                            Haltbarkeit
- 12 months
 
- 
                                            
- 
    - Cyclin C (CCNC)
- 
                                            Andere Bezeichnung
- CCNC
- 
                                            Hintergrund
- 
                        Description: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Gene: CCNC 
- 
                                            Molekulargewicht
- 33 kDa
- 
                                            Gen-ID
- 892
- 
                                            UniProt
- P24863
- 
                                            Pathways
- Zellzyklus, Regulation of Lipid Metabolism by PPARalpha
 Target
- 
                    
 
                                     
                                     
                                    