COLEC12 Antikörper (C-Term)

Produktnummer ABIN6260935

Dieses Anti-COLEC12-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von COLEC12 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für COLEC12 Antikörper (C-Term) (ABIN6260935)

Target: COLEC12 (Collectin Sub-Family Member 12 (COLEC12))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COLEC12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-COLEC12 Antikörper

Bindungsspezifität: C-Term

Spezifität: COLEC12 Antibody detects endogenous levels of total COLEC12.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human COLEC12, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu COLEC12

Target: COLEC12 (Collectin Sub-Family Member 12 (COLEC12))

Andere Bezeichnung: COLEC12

Hintergrund:

Description: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.

Gene: COLEC12

Molekulargewicht: 82 kDa

Gen-ID: 81035

UniProt: Q5KU26

Pathways: Activation of Innate immune Response