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CENPE Antikörper (C-Term)

CENPE Reaktivität: Human WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6260750
  • Target Alle CENPE Antikörper anzeigen
    CENPE (Centromere Protein E, 312kDa (CENPE))
    Bindungsspezifität
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 37
    • 3
    • 2
    Human
    Wirt
    • 28
    • 7
    • 3
    Kaninchen
    Klonalität
    • 31
    • 7
    Polyklonal
    Konjugat
    • 21
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CENPE Antikörper ist unkonjugiert
    Applikation
    • 23
    • 17
    • 8
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    CENPE Antibody detects endogenous levels of total CENPE.
    Homologie
    Pig,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CENPE, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CENPE Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    CENPE (Centromere Protein E, 312kDa (CENPE))
    Andere Bezeichnung
    CENPE (CENPE Produkte)
    Synonyme
    CENP-E antikoerper, KIF10 antikoerper, PPP1R61 antikoerper, 312kDa antikoerper, AU019344 antikoerper, BC049989 antikoerper, C530022J18 antikoerper, Kif10 antikoerper, CENPE antikoerper, kif10 antikoerper, cenp-E antikoerper, XCENP-E antikoerper, wu:fc06a10 antikoerper, zgc:152925 antikoerper, centromere protein E antikoerper, centromere protein E, 312kDa antikoerper, CENPE antikoerper, Cenpe antikoerper, cenpe antikoerper
    Hintergrund

    Description: Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips, after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity).

    Gene: CENPE

    Molekulargewicht
    312 kDa
    Gen-ID
    1062
    UniProt
    Q02224
    Pathways
    M Phase, Maintenance of Protein Location
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