ARHGEF4 Antikörper (Internal Region)

Produktnummer ABIN6260035

Produktdetails anti-ARHGEF4 Antikörper

Target: ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGEF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: ARHGEF4 Antibody detects endogenous levels of total ARHGEF4.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ARHGEF4, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ARHGEF4

Target: ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))

Andere Bezeichnung: ARHGEF4 (ARHGEF4 Produkte)

Synonyme: ARHGEF4 antikoerper, ASEF antikoerper, ASEF1 antikoerper, GEF4 antikoerper, STM6 antikoerper, 9330140K16Rik antikoerper, Asef antikoerper, ENSMUSG00000070955 antikoerper, Rho guanine nucleotide exchange factor 4 antikoerper, uncharacterized LOC100470646 antikoerper, rho guanine nucleotide exchange factor 4 antikoerper, Rho guanine nucleotide exchange factor (GEF) 4 antikoerper, ARHGEF4 antikoerper, arhg4 antikoerper, LOC100470646 antikoerper, LOC100544917 antikoerper, Arhgef4 antikoerper

Hintergrund:

Description: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Gene: ARHGEF4

Molekulargewicht: 79 kDa

Gen-ID: 50649

UniProt: Q9NR80

Pathways: Neurotrophin Signalübertragung