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ARHGEF4 Antikörper (AA 143-271)

ARHGEF4 Reaktivität: Human WB, FACS Wirt: Maus Monoclonal ARHGEF-08 unconjugated
Produktnummer ABIN2749042
  • Target Alle ARHGEF4 Antikörper anzeigen
    ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 143-271
    Reaktivität
    • 31
    • 12
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 26
    • 4
    • 1
    Maus
    Klonalität
    • 28
    • 3
    Monoklonal
    Konjugat
    • 11
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ARHGEF4 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 17
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody ARHGEF-08 recognizes human intracellular protein ARHGEF4 / ASEF1, approx. 80 kDa guanine nucleotide exchange factor specific for Rac1 and Cdc42. The epitope is located in the rough at the region of SH3 domain.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Recombinant fragment of human ARHGEF4 (amino acids 143-271)
    Klon
    ARHGEF-08
    Isotyp
    IgG1
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  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Target
    ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
    Andere Bezeichnung
    ARHGEF4 (ARHGEF4 Produkte)
    Synonyme
    ARHGEF4 antikoerper, ASEF antikoerper, ASEF1 antikoerper, GEF4 antikoerper, STM6 antikoerper, 9330140K16Rik antikoerper, Asef antikoerper, ENSMUSG00000070955 antikoerper, Rho guanine nucleotide exchange factor 4 antikoerper, uncharacterized LOC100470646 antikoerper, rho guanine nucleotide exchange factor 4 antikoerper, Rho guanine nucleotide exchange factor (GEF) 4 antikoerper, ARHGEF4 antikoerper, arhg4 antikoerper, LOC100470646 antikoerper, LOC100544917 antikoerper, Arhgef4 antikoerper
    Hintergrund
    Rho guanine nucleotide exchange factor 4,ARHGEF4 (Rho guanine nucleotide exchange factor 4), also known as ASEF 1 (adenomatous polyposis coli –, stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH), pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain, whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42, which leads to decreased cell-cell adherence and enhanced cell migration.,ASEF1, GEF4, STM6
    Gen-ID
    50649
    UniProt
    Q9NR80
    Pathways
    Neurotrophin Signalübertragung
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