PARP2 Antikörper (Internal Region)
Kurzübersicht für PARP2 Antikörper (Internal Region) (ABIN6259061)
Target
Alle PARP2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- Internal Region
-
Spezifität
- PARP2 Antibody detects endogenous levels of total PARP2.
-
Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog
-
Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
Immunogen
- A synthesized peptide derived from human PARP2, corresponding to a region within the internal amino acids.
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 1 mg/mL
-
Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
-
Haltbarkeit
- 12 months
-
-
- PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))
-
Andere Bezeichnung
- PARP2
-
Hintergrund
-
Description: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1, HPF1 conferring serine specificity (PubMed:28190768).
Gene: PARP2
-
Molekulargewicht
- 75 kDa
-
Gen-ID
- 10038
-
UniProt
- Q9UGN5
-
Pathways
- DNA Reparatur
Target
-