NCOA1 Antikörper (Internal Region)

Produktnummer ABIN6257367

Der Kaninchen Polyklonal anti-NCOA1 Antikörper wird verwendet zum Nachweis von NCOA1 in Proben von Human, Maus, Ratte und Affe. Er wurde validiert für WB.

Kurzübersicht für NCOA1 Antikörper (Internal Region) (ABIN6257367)

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NCOA1 Antikörper

Bindungsspezifität: Internal Region

Verwendungszweck: KAT13A/SRC1 Antibody

Spezifität: NCOA1 antibody detects endogenous levels of total NCOA1

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KAT13A/SRC1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NCOA1

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Andere Bezeichnung: KAT13A/SRC1

Hintergrund:

Description: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Gene: NCOA1

Molekulargewicht: 200 kDa

Gen-ID: 8648

UniProt: Q15788

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha