AIM2 Antikörper (Internal Region)

Produktnummer ABIN6256925

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch AIM2 in WB, ELISA, IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für AIM2 Antikörper (Internal Region) (ABIN6256925)

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AIM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-AIM2 Antikörper

Bindungsspezifität: Internal Region

Spezifität: AIM2 Antibody detects endogenous levels of total AIM2.

Homologie: Horse

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human AIM2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu AIM2

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Andere Bezeichnung: AIM2

Hintergrund:

Description: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Gene: AIM2

Molekulargewicht: 39 kDa

Gen-ID: 9447

UniProt: O14862

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome