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MAPT Antikörper (pSer214)

Dieses Anti-MAPT-Antikörper ist ein Rabbit Polyclonal-Antikörper zur Detektion von MAPT in WB, ELISA, IHC. Geeignet für Human, Rat, Mouse.
Produktnummer ABIN6256195

Kurzübersicht für MAPT Antikörper (pSer214) (ABIN6256195)

Target

Alle MAPT Antikörper anzeigen
MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität

  • 246
  • 119
  • 114
  • 15
  • 7
  • 6
  • 6
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 222
  • 31
  • 7
  • 2
  • 1
Kaninchen

Klonalität

  • 197
  • 66
Polyklonal

Konjugat

  • 216
  • 17
  • 6
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Dieser MAPT Antikörper ist unkonjugiert

Applikation

  • 218
  • 140
  • 89
  • 39
  • 38
  • 29
  • 17
  • 7
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 12
    • 9
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer214

    Spezifität

    Phospho-Tau (Ser214) Antibody detects endogenous levels of Tau only when phosphorylated at Serine 214.

    Homologie

    Pig,Bovine,Horse,Rabbit,Dog,Chicken

    Aufreinigung

    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

    Immunogen

    A synthesized peptide derived from human Tau around the phosphorylation site of Ser214.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    MAPT (Microtubule-Associated Protein tau (MAPT))

    Andere Bezeichnung

    MAPT

    Hintergrund

    Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

    Gene: MAPT

    Molekulargewicht

    78kDa

    Gen-ID

    4137

    UniProt

    P10636

    Pathways

    MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size
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