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PERK Antikörper (pThr982)

Der Kaninchen Polyklonal Anti-PERK-Antikörper wurde für WB, ELISA, IHC, IF und ICC validiert. Er ist geeignet, PERK in Proben von Human, Maus und Ratte zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN6255756

Kurzübersicht für PERK Antikörper (pThr982) (ABIN6255756)

Target

Alle PERK (EIF2AK3) Antikörper anzeigen
PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Reaktivität

  • 96
  • 60
  • 57
  • 16
  • 16
  • 1
Human, Maus, Ratte

Wirt

  • 90
  • 6
  • 3
  • 1
Kaninchen

Klonalität

  • 92
  • 8
Polyklonal

Konjugat

  • 42
  • 9
  • 8
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PERK Antikörper ist unkonjugiert

Applikation

  • 74
  • 52
  • 42
  • 29
  • 26
  • 26
  • 12
  • 11
  • 9
  • 6
  • 6
  • 5
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 16
    • 16
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr982

    Spezifität

    Phospho-PERK (Thr982) Antibody detects endogenous levels of PERK only when phosphorylated at Thr982.

    Homologie

    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

    Aufreinigung

    Immunogen affinity purified

    Immunogen

    A synthesized peptide derived from human PERK around the phosphorylation site of Thr982.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Cai, Zheng, Gu, Wang, Wang, Yang, Zhang, Wang, Fu, Wang: "Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78." in: Cell death & disease, Vol. 9, Issue 6, pp. 636, (2018) (PubMed).

    Liu, Shen, Wang, Liu, Zheng, Luo: "EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes." in: Journal of cellular biochemistry, (2018) (PubMed).

    Yao, Lu, Hu, Yu, Chen, Wang: "A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure." in: Nature communications, Vol. 8, Issue 1, pp. 133, (2017) (PubMed).

  • Target

    PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

    Andere Bezeichnung

    EIF2AK3

    Hintergrund

    Description: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

    Gene: EIF2AK3

    Molekulargewicht

    125 kDa

    Gen-ID

    9451

    UniProt

    Q9NZJ5

    Pathways

    Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response
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