FAT Atypical Cadherin 2 (FAT2) Antikörper

Produktnummer ABIN6251792

Dieses Anti--Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von in IF, FACS, IHC und WB. Geeignet für Human.

Kurzübersicht für FAT Atypical Cadherin 2 (FAT2) Antikörper (ABIN6251792)

Target: FAT Atypical Cadherin 2 (FAT2)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)

Klon: 8C5

Produktdetails

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant human Protocadherin Fat 2 fusion protein was used as the immunogen for this FAT2 antibody.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml

Immunofluorescence: 1-2 μg/mL

IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT

Titering of the FAT2 antibody may be required for optimal performance.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Antigendetails

Target: FAT Atypical Cadherin 2 (FAT2)

Andere Bezeichnung: FAT2

Hintergrund: Recognizes a protein of 480  kDa, which is identified as FAT2. The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell-to-cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT2 (FAT tumor suppressor homolog 2) is a single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins. FAT2 contains one Laminin G-like domain, two EGF-like domains and 32 cadherin domains and is believed to function as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development.

Gen-ID: 2196

UniProt: Q9NYQ8