RSPO1 Antikörper (AA 206-240)

Produktnummer ABIN6244080

Der Kaninchen Polyklonal Anti-RSPO1-Antikörper wurde für WB validiert. Er ist geeignet, RSPO1 in Proben von Human zu detektieren.

Kurzübersicht für RSPO1 Antikörper (AA 206-240) (ABIN6244080)

Target: RSPO1 (R-Spondin 1 (RSPO1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RSPO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB54226

Produktdetails anti-RSPO1 Antikörper

Bindungsspezifität: AA 206-240

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RSPO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 206-240 amino acids from human RSPO1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu RSPO1

Target: RSPO1 (R-Spondin 1 (RSPO1))

Andere Bezeichnung: RSPO1

Hintergrund: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Molekulargewicht: 28959

UniProt: Q2MKA7