RSPO1 Antikörper

Produktnummer ABIN969375

Zitiert in 2+ Publikationen. Der Maus Monoklonal anti-RSPO1 Antikörper (Klon 7A6) (ABIN969375) detektiert spezifisch RSPO1 in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für RSPO1 Antikörper (ABIN969375)

Target: RSPO1 (R-Spondin 1 (RSPO1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RSPO1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 7A6

Produktdetails anti-RSPO1 Antikörper

Verwendungszweck: R-spondin1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of R-spondin1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-RSPO1 Antikörper (ABIN969375)

Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).

Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." in: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).

Details zu RSPO1

Target: RSPO1 (R-Spondin 1 (RSPO1))

Andere Bezeichnung: R-spondin1

Hintergrund: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Molekulargewicht: 28.9 kDa

Gen-ID: 284654

UniProt: Q2MKA7