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LIN28A Antikörper (N-Term)

This anti-LIN28A antibody (ABIN6243719) is a Rabbit Polyclonal antibody detecting LIN28A in WB. Suitable for Human.
Produktnummer ABIN6243719

Kurzübersicht für LIN28A Antikörper (N-Term) (ABIN6243719)

Target

Alle LIN28A Antikörper anzeigen
LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Reaktivität

  • 98
  • 31
  • 28
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 83
  • 19
Kaninchen

Klonalität

  • 77
  • 25
Polyklonal

Konjugat

  • 52
  • 7
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LIN28A Antikörper ist unkonjugiert

Applikation

  • 66
  • 39
  • 26
  • 23
  • 19
  • 14
  • 13
  • 13
  • 11
  • 10
  • 9
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB)

Klon

RB51185
  • Bindungsspezifität

    • 15
    • 9
    • 9
    • 7
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 22-56, N-Term

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This LIN28A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 22-56 amino acids from the N-terminal region of human LIN28A.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

    Andere Bezeichnung

    LIN28A

    Hintergrund

    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 [removed]By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let- 7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre- let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

    Molekulargewicht

    22743

    UniProt

    Q9H9Z2

    Pathways

    Stem Cell Maintenance
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